Inoperable rectal tumour, no metastases: A radio-chemotherapy with a favourable response surgery B radio-chemotherapy with a non-favourable response chemotherapy Operable rectal cancer colon t3, with metastases: radical surgery of the tumour with resection hpv cancer high risk the hepatic or lung metastasis radio-chemotherapy radio-chemotherapy followed by surgical treatment.
Non-operable cancer colon t3 tumour with metastases: chemotherapy and radiotherapy. We must remember that the rectum is a fix organ, that represents an advantage for the irradiation process.
The preoperative irradiation has the advantage cancer colon t3 preventing the excessive irradiation of other cavity organs, as in the case of cancer colon t3 postoperative irradiation, when the small bowel loops drop in the pelvis. This protocol has been established starting from the actual knowledge regarding the genetics of rectal cancer, and also the studies of fundamental and clinical research which cancer colon t3 the response of the rectal cancer to different treatment methods.
The oncogenesis is determined by the alternation of the cellular cycle, and initiates the appearance of angiogenesis. Citokines such as the fibroblastic growth factor, the endothelial growth factor, angiogenin and interleukin 8 mediate and are the promoters of angiogenesis.
Those are produced by the tumor cells, T lymphocytes and by other stromal cells. Also, the macrophages and the tumor cells produce urokinase plasminogen activatorwhich favours angiogenesis.
The tumour angiogenesis is responsible for the tumour behaviour, lymphatic metastases and the distant metastases.
- Platyhelminthes nemathelminthes ppt
- Condyloma acuminata cdc
- N2a M0 Cancerul s-a răspândit dincolo de colon sau rect incluzând peritoneul visceral dar nu a ajuns încă la organele învecinate T4a.
- Cancerul colorectal: Ce este și cum îl prevenim?, Cancer colon t3
- Tratament viermisori copii
The genetic studies have shown that mutations in the p53 suppressor gene may determine the cell production of inhibitors of the apoptosis, which make the tumour cells resistant to chemo-radiotherapy.
The evaluation of the status of the p53 gene might cancer colon t3 the appreciation of the tumour aggressiveness in case of a partially located lesion, the response to PCT 5FUthe survival after curative resection, and of the prognostic 2.
It is cancer colon t3 known fact that the tissue response to irradiation depends of: The cellular apoptosis through disruptions at the DNA level and through the production of free oxygen radicals. The cellular destructions that affect tumour proliferation. The fibrosis and the densification of the rectal wall.
Diagnosticul imagistic al tumorilor colo-rectale
The obliterating arteritis through hyalinisation process. The blockage of the cells which block the apoptosis. The destruction of the micro-angiogenesis network. It must be cancer colon t3 that hypoxia decreases the destruction of the tumour cells.
Analize de sânge - Analize de laborator
The different response to radiotherapy is conditioned by several factors: The tumour dimensions The cellular phenotype The tumour angiogenesis. The type of the peri-tumour inflammatory infiltrate - the tumours with mixt infiltrate have a better prognosis. The intra-tumour microvascular density the greatest number of vascular lumen without a muscular wall in an cancer colon t3 field 40X.
The response to radio-chemotherapy may be appreciated: Macroscopic: The decrease of the tumour dimensions Conversions to a more inferior stage.
The post-radiotherapy regression reaction was quantified by Bazzetti inwho established 5 degrees of regression of the rectal tumour after radiotherapy. R5 - the absence of the regression. A good response to R2 radiotherapy almost complete regression was achieved in nearly Therefore, cancer colon t3 can say that the radiotherapy response was correlated directly with the cancer colon t3 stage of the disease, being favourable for patients in stage II of evolution and weak for those in stage III 3.
Under these conditions, a very important problem is the identification of the degree of response to radiotherapy of the tumour and also to the metastases potential, as long-term radiotherapy lasts approximately 4 weeks, to which one may add around a minimum of weeks until the moment in which the patient will cancer colon t3 operated on, a total of weeks. If the tumour has a low potential for the radiotherapy response, but a high potential for metastases, the benefit of radiotherapy will be decreased and the risk of metastasis will increase exponentially, taking into account cancer colon t3 fact that radiotherapy is a form of local treatment and does not prevent metastases.
It is to be noticed that the data of the cancer colon t3 studies are inconstant and have not allowed so far the identification of a genetic marker of predisposition of the rectal tumours to radio-chemotherapy.
- Does hpv cause lung cancer
- Weken zwanger en diarree
- Sălbatic din ce viermi
- Autor: Dr.
- Helmintiaza cronică la adulți
- Medicamente pentru copiii viermilor de vierme
- NCLEX-RN: Oncology Nursing - Brilliant Nurse®
- Cancerul de colon
Another problem that we would like to analyze is regarded to the attitude towards the patients with an R1 cancer colon t3 in the Bazetti cancer colon t3.
In the treatment guide of the Ministry of Health for colorectal carcinoma in stage I TNM TN0M0it is mentioned that, in carefully selected cases which are correctly staged preoperatively, in centres with experience, one might choose local transanal resection, exclusive radiotherapy or a cancer colon t3 between radiotherapy and limited surgery.
(PDF) Clasificare stadializare bune | Alina Ionita - granturieuropene.ro
Cancer colon t3 post-radiotherapy regression R0 and its follow-up wait-and-see has the advantage that the patients are spared the complications of surgery and there are two studies mentioned Habr-Gama et al.
Nevertheless, we must state the fact that the surgical treatment in rectal cancer may cancer colon t3 the following complications: Abdominal perineal resection: Impair of the sexual activity Decrease of the quality of life Para-stomal hernia. One must remember that the physiologic mechanisms of defecation are the more affected as the resection descends at the level of the rectum, so that in the case of ultralow resections and in those with colo-anal anastomosis, they are completely disappeared.
Some of these potential complications induce a big discomfort for the patient and produce a degree of invalidity. They may represent reasons for accusation of malpraxis in the case of a patient in which the anatomical specimen does no longer contain tumour tissue after radiotherapy, and which in the postoperative period remains one of the downfalls of the surgery of the rectum.